Quinoline, 4-chloro-8-nitro- is an organic compound that belongs to the class of quinolines, which are bicyclic aromatic compounds containing a fused benzene and pyridine ring. This particular compound features a chlorine atom at the 4-position and a nitro group at the 8-position of the quinoline structure, which contributes to its chemical reactivity and potential applications. It is typically a yellow to brown solid at room temperature and is sparingly soluble in water but more soluble in organic solvents. The presence of the nitro group can impart significant electrophilic character, making it useful in various chemical reactions, including nitration and substitution processes. Quinoline derivatives are often studied for their biological activities, including antimicrobial and antitumor properties. Safety data indicates that, like many nitro compounds, it may pose health risks, necessitating appropriate handling and storage precautions. Overall, 4-chloro-8-nitro-quinoline serves as an important compound in both synthetic organic chemistry and medicinal chemistry research.

Quinoline, 4-chloro-8-nitro-

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4-Chloro-8-nitroquinoline

4-Chloro-8-nitroquinoline is a postulated carcinogen that has been shown to cause cancer in animals. It has also been shown to induce skin cancer in humans. 4-Chloro-8-nitroquinoline is a nucleophile that reacts with DNA, RNA and proteins by forming covalent bonds. In addition, this chemical can react with nitrous acid to form reactive intermediates that may bind to DNA and cause mutations. Analysis of the absorption spectra of this compound shows a strong peak at 285 nm, which is consistent with the nitro group. The technique of nuclear magnetic resonance (NMR) was used to analyze diploid cells for the presence of 4-chloro-8-nitroquinoline and found a concentration of 0.1 mM. This analysis suggests that this chemical binds preferentially to DNA and causes mutations in diploid cells.

CAS 23833-99-0: Quinoline, 4-chloro-8-nitro-

4-Chloro-8-nitroquinoline

Ref: 54-OR90689

4-Chloro-8-nitroquinoline

Ref: IN-DA007N1E

4-Chloro-8-nitroquinoline

Ref: 3D-FC133242

4-Chloro-8-nitroquinoline

Ref: 10-F239870