CAS 2417-72-3: Methyl 4-(bromomethyl)benzoate

Applications 4-(Bromomethyl)benzoic Acid Methyl Ester is an ester derivative of a bromoalkylated benzoic acid. 4-(Bromomethyl)benzoic Acid Methyl Ester is used in the preparation of potential anti-HIV agents. It is also used as a catalyst for rearrangement of benzylthiothiazoline derivatives in the preparation aldose reductase inhibitors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Cushman, M. et al.: Bioorg. Med. Chem. Lett., 8, 833 (1998); Nagao, Y. et al.: Chem. Pharmac. Bull., 36, 509 (1988);

Methyl 4-(bromomethyl)benzoate

Methyl 4-bromomethylbenzoate is an aryl halide with the chemical formula CHBr. It is an orally effective and selective apoptosis pathway inhibitor that blocks the release of tumor necrosis factor-α (TNF-α) induced by lipopolysaccharides in monocytes. Methyl 4-bromomethylbenzoate has also been shown to inhibit matrix metalloproteinase activity in vitro, which may be due to its ability to block the cleavage of proteoglycan precursors. The molecular modeling studies have revealed that this agent binds to DNA through a hydrophobic pocket, which inhibits transcription and replication. Methyl 4-bromomethylbenzoate has also been shown to be active against cancer cells and induce apoptosis through caspase activation and mitochondrial dysfunction.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Methyl 4-(bromomethyl)benzoate is used in the preparation of potential anti-HIV agents. It i s also used as a catalyst for rearrangement of benzylthiothiazoline derivatives in the preparation aldose reductase inhibitors. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.