CAS 2457-76-3: 4-Amino-2-chlorobenzoic acid

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

4-Amino-2-chlorobenzoic acid

4-Amino-2-chlorobenzoic acid (4ACBA) is a pharmaceutical chemical that is used in the preparation of pharmaceutical preparations. 4ACBA has been shown to be absorbed through the maternal blood and have an inhibitory effect on rat sciatic nerve. The uptake of 4ACBA was found to be dose dependent, with a maximum concentration reached after 30 minutes. The pharmacokinetic properties of 4ACBA have been shown to be nonlinear, with plasma concentrations decreasing as dosage increases. The following product details are for a fitness supplement:

4-Amino-2-chlorobenzoic acid (4ACB) is a drug that inhibits the absorption of other drugs by binding to their active sites. It is used as an analytical reagent in chromatographic methods for determining protein concentration, and has been shown to be effective in reducing pain in animal models. 4ACB has also been shown to have ochronotic properties, which may be due to its ability to inhibit the formation of reactive oxygen species. 4ACB binds with high affinity to the plasma proteins albumin and alpha1-acid glycoprotein, with a binding constant of 10-8 M. The elimination half-life of 4ACB is approximately 27 hours, and it is excreted primarily through the kidneys.