CAS 245747-08-4: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoropyridine-4-carboxamide

Pyr6

Pyr6 is a small molecule inhibitor, which is derived from synthetic organic chemistry with a specific mode of action targeting signaling pathways. Its main mechanism involves the inhibition of transient receptor potential (TRP) channels, specifically TRPV6, which plays a critical role in calcium influx in cells. By inhibiting TRPV6, Pyr6 effectively disrupts calcium signaling, which is pivotal in various cellular processes, including proliferation and differentiation. Pyr6 is primarily used in the context of cancer research due to its ability to reduce cellular calcium influx, thereby inducing cytotoxicity in cancerous cells. It has shown promising applications in preclinical studies, particularly in types of cancer where TRPV6 overexpression is prevalent. Pyr6 aids in understanding carcinogenic pathways and has potential therapeutic implications, offering insights that could lead to the development of new cancer treatments targeting calcium signaling.

Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx