CAS 2458-08-4: 12-Ketochenodeoxycholic acid

(3a,5b,7a)-3,7-Dihydroxy-12-oxo-cholan-24-oic acid is a bile acid derivative, which is a type of naturally occurring steroid acid found predominantly in the bile of mammals. Bile acids play a crucial role in the digestion and absorption of lipids in the small intestine. This compound is synthesized from cholesterol in the liver, where it functions in the emulsification of dietary fats. The mechanism of action of (3a,5b,7a)-3,7-Dihydroxy-12-oxo-cholan-24-oic acid involves the reduction of cholesterol levels by converting cholesterol into bile acids, which are then excreted. This conversion not only aids lipid digestion but also regulates cholesterol homeostasis. The compound may also interact with farnesoid X receptors (FXR), influencing liver metabolism and detoxification processes. This bile acid derivative finds applications in scientific research related to liver function, cholesterol management, and potentially in pharmacological therapy for liver diseases such as primary biliary cholangitis. Its biochemical properties allow it to serve as a substrate for investigating metabolic processes and liver health.