CAS: 2471-69-4

6-Methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (MTN) is a polyphenol that has been shown to be effective against Alzheimer's disease in vitro and in vivo. MTN is able to bind to the polymerase chain reaction (PCR) product of APP and inhibit it from binding to heme oxygenase. MTN also prevents the accumulation of amyloid plaques by inhibiting the formation of beta-amyloid protein. MTN binds to thioflavin T and can be used as a fluorescent probe for immunofluorescence staining. MTN also inhibits the expression levels of APP and PS1 proteins in APP/PS1 transgenic mice by modulating the activity of transcriptional factors such as CREB.