Nucleocidin, with the CAS number 24751-69-7, is a nucleoside antibiotic that exhibits notable antibacterial properties. It is derived from the fermentation of certain strains of the bacterium *Streptomyces griseus*. Nucleocidin is characterized by its unique structure, which includes a purine base linked to a ribose sugar, contributing to its biological activity. This compound primarily functions by inhibiting bacterial RNA synthesis, making it effective against a range of Gram-positive bacteria. Its mechanism of action involves interference with the transcription process, which is crucial for bacterial growth and replication. Nucleocidin has been studied for its potential therapeutic applications, particularly in treating infections caused by resistant bacterial strains. However, its clinical use may be limited due to potential toxicity and side effects. As with many antibiotics, the development of resistance is a concern, necessitating careful consideration in its application. Overall, nucleocidin represents an important compound in the field of antibiotic research, highlighting the ongoing need for effective antimicrobial agents.

Nucleocidin

24751-69-7: 24751-69-7, 4′-Fluoro-5′-O-sulfamoyladenosine, Adenosine, 4′-C-fluoro-, 5′-sulfamate, NSC 521007, Nucleocidin, [(2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-2-fluoro-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate (non-preferred name)

Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.

Applications Nucleocidin is used in studies relating to novel parasite inhibitors.
References Dixit, S. et al.: Org. Biomol. Chem., 10, 6121 (2012); Fukuda, K. et al.: Actinomycet., 23, 51 (2009);


4'-C-Fluoroadenosine 5'-sulfamate is a molecule that inhibits protein synthesis by binding to the ribosomes of bacteria. It also has anti-angiogenic effects and can be used as an antimicrobial agent against staphylococci, streptococci, and mycobacteria. 4'-C-Fluoroadenosine 5'-sulfamate has minimal toxicity in humans and is not active against Saccharomyces cerevisiae or Escherichia coli. The optimum concentration for inhibiting protein synthesis in vitro was determined to be between 100 and 500 μM. This compound is inexpensive and can be synthesized from commercially available starting materials. In cell culture assays, this compound showed antimicrobial activity against staphylococci, streptococci, and mycobacteria with MIC values ranging from 0.03 to 1 mM.br>
4'-C-Fluoroadenosine 5'-s

CAS 24751-69-7: Nucleocidin

Nucleocidin

Ref: TM-T16361

Nucleocidin

Ref: TR-N925200

4'-C-Fluoroadenosine 5'-sulfamate

Ref: 3D-NF76155