CAS 24932-48-7: 4,5-Dibromo-o-xylene

Applications 1,2-Dibromo-4,5-dimethylbenzene is used as a reagent in the synthesis of Thalidomide (T338850); an inhibitor of FGF-induced angiogenesis and replication of human immunodeficiency virus type 1. Also a teratogenic sedative and immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma. References Chen, J., et al.: Org. Biomol. Chem., 12, 5578 (2014); D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994); Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993); Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)

1,2-Dibromo-4,5-dimethylbenzene

4,5-Dibromo-o-xylene is used in the synthesis of organometallic compounds. It is a processable chemical that has been shown to have a red shift in the photophysical spectrum when compared to other substituted benzene derivatives. The presence of phenyl substituents on 4,5-dibromo-o-xylene can lead to elimination reactions with diphosphine or other electrophiles. 4,5-Dibromo-o-xylene can be analyzed by NMR spectroscopy and has been shown to have an analytical method for determining its purity.

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