CAS 2524-64-3: Diphenyl chlorophosphate

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Diphenyl phosphorochloridate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5',5'-triphosphate, guanosine-cytidine-5',5'-triphosphate, guanosine-uridine-5',5'-triphosphate, diguanosine-5',5'-diphosphate and diguanosine-5',5'-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Diphenyl chlorophosphate is a reactive molecule that is classified as an organic compound. It has been synthesized in vitro by reacting sodium carbonate with p-hydroxybenzoic acid and trifluoroacetic acid. The synthesis of this compound was successful because the hydroxyl group on p-hydroxybenzoic acid reacted with the amide group on sodium carbonate to form an amide linkage. This reaction also created an alkanoic acid, which was hydrolyzed to form an ester linkage between the two molecules. Diphenyl chlorophosphate has been shown to bind to receptor molecules and inhibit their activity, which may be due to its ability to react with other molecules in order to produce a new product.

Diphenyl chlorophosphate

Applications Diphenyl Chlorophosphonate, is a building block used for the synthesis of various chemical compounds. It can be used for the synthesis of phosphate esters of polyhedral hydroxyboranes, showing enhanced tumor uptake. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bechtold, R., et al.: J. Med. Chem., 18, 371 (1975);