CAS 25311-71-1: Isofenphos

Isofenphos is a type of chemical that has a broad spectrum of activity and inhibits target enzymes in the growth of microorganisms. It is used in the nutrient solution to kill Abalone and Haliotis. Isofenphos has been shown to inhibit bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Isofenphos also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Applications Isofenphos is a pesticide residue found in plant based food that may have acute health risks for consumers. References Skretteberg, L.G., et. al.: Food Control, 51, 225 (2015)