CAS 253863-19-3: (3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Formula:C19H22O7
InChI:InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
InChI key:InChIKey=NEQZWEXWOFPKOT-BYRRXHGESA-N
SMILES:OC1=C2C(=CC(OC)=C1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O
Synonyms:- (3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
- (5Z)-7-Oxozeaenol
- 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-
- 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione,3,- 4,9,10-tetrahydro-8,9,16-trihydroxy-14- methoxy-3-methyl-,(3S,5E,8S,9S,11E)-
- C 292
- F 152
- Fr 148083
- L 783279
- f 152 A<sub>1</sub>
- LL-Z 1640-2
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Found 5 products.
LL-Z-1640-2
CAS:LL-Z-1640-2Formula:C19H22O7Purity:By hplc: 100.0% (Typical Value in Batch COA)Color and Shape: whitish powderMolecular weight:362.37g/mol5Z-7-Oxozeaenol
CAS:5Z-7-Oxozeaenol: TGF-β-activated kinase 1 inhibitor, IC50 8.1 nM; VEGF-R2 inhibitor, IC50 52 nM; weak MEK1 inhibitor, IC50 411 nM.Formula:C19H22O7Purity:99%Color and Shape:SolidMolecular weight:362.375Z-7-Oxozeaenol
CAS:Formula:C19H22O7Purity:≥ 98.0%Color and Shape:White or off-white solidMolecular weight:362.37(5Z)-7-Oxozeaenol
CAS:(5Z)-7-Oxozeaenol is a potent and selective small-molecule inhibitor, primarily characterized as a natural product derived from fungal sources. It specifically targets and inhibits transforming growth factor-beta (TGF-β) type I receptor kinase, also known as activin receptor-like kinase 5 (ALK5), as well as TAO kinases. The inhibition occurs through covalent modification, which results in the suppression of downstream signaling pathways that are crucial in various cellular processes. Used extensively in biochemical and pharmacological research, (5Z)-7-Oxozeaenol is invaluable for studying the complex signaling pathways involved in cell growth, differentiation, and apoptosis. Its role in inhibiting specific protein kinases makes it a critical tool for investigating the molecular mechanisms underlying fibrotic diseases, cancer development, and other kinase-related pathologies. Additionally, its distinct mode of action helps elucidate cellular responses to kinase inhibition, contributing to the development of novel therapeutic strategies.Formula:C19H22O7Purity:Min. 95%Color and Shape:PowderMolecular weight:362.37 g/mol
