CAS: 2561476-24-0

compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an

4-((4-(2,4-Dichlorophenyl)-3-ethylthiazol-2(3H)-ylidene)amino)benzenesulfonamide is an inhibitor of the enzyme acetylcholine esterase (AChE), which is involved in the breakdown of the neurotransmitter acetylcholine. The compound was originally developed as a potential therapeutic for Alzheimer's disease and Parkinson's disease because it inhibits the activity of AChE. However, 4-((4-(2,4-dichlorophenyl)-3-ethylthiazol-2(3H)-ylidene)amino)benzenesulfonamide also has been shown to inhibit a number of other enzymes including phosphodiesterase (PDE), monoamine oxidase (MAO), and catechol O methyltransferase (COMT). It has also been shown to activate certain proteins such as PKC.

EMAC10101d