CAS: 25967-34-4

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Loxapine N-oxide is a metabolite of loxapine. It has been shown that the n-oxide form of loxapine has regulatory effects on the metabotropic glutamate receptor and can be used to treat symptoms of schizophrenia. Loxapine N-oxide has been shown to have antipsychotic effects in vitro. The structural formula for loxapine N-oxide is as follows: Loxapine N-oxide is an active metabolite of loxapine, which is a neuroleptic drug that blocks dopamine receptors and antagonizes serotonin receptors. Loxapine N-oxide binds to the CB1 receptor and regulates its activity, which may be useful for treating schizophrenia symptoms.

Stability Hygroscopic, Light Sensitive Applications Loxapine N-Oxide is a metabolite of Loxapine (L472750), a D2/D4-Dopamine receptor antagonist. It is a serotonergic receptor antagonist that acts as a dibenzoxazepine antipsychotic agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Shen, Y., et al.: J. Biol. Chem., 268, 18200 (1993), Fiorella, D., et al.: Psychopharmacology, 121, 347 (1995), Glusa, E., et al.: Br. J. Pharmacol., 130, 692 (2000)