CAS 26304-61-0: Azepindole

Azepindole is a prodrug that is converted to azepindole-5-carboxylic acid, its active form, in the liver. Azepindole has been shown to be effective against inflammatory bowel disease and may be useful for the diagnosis of this disease. It is also used for the treatment of bowel diseases such as ulcerative colitis and Crohn's disease. The most common side effects are nausea, vomiting, diarrhea, and abdominal pain. The drug works by inhibiting serotonin reuptake transporter gene (SERT) in the intestine. This prevents serotonin from binding to SERT and thereby decreases serotonin release in the intestine. Azepindole inhibits the activity of enzymes involved in fatty acid synthesis by blocking the incorporation of acetyl-CoA into fatty acids.