CAS 264218-23-7: SB 415286
Formula:C16H10ClN3O5
InChI:InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
InChI key:InChIKey=PQCXVIPXISBFPN-UHFFFAOYSA-N
SMILES:N(C1=C(C(=O)NC1=O)C2=C(N(=O)=O)C=CC=C2)C3=CC(Cl)=C(O)C=C3
Synonyms:- 1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-
- Sb 415286
- 3-[(3-Chloro-4-hydroxyphenyl)-amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione
- 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
- 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
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Found 5 products.
1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-
CAS:Formula:C16H10ClN3O5Purity:98%Color and Shape:SolidMolecular weight:359.7207SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Formula:C16H10ClN3O5Purity:99.55%Color and Shape:SolidMolecular weight:359.72SB-415286
CAS:SB-415286 is a small molecule inhibitor of GSK-3β. It prevents phosphorylation of the substrate by GSK-3β, thereby preventing the inhibition of downstream signaling pathways, such as those that regulate energy metabolism and neuronal death. SB-415286 has been shown to inhibit 3t3-l1 preadipocytes differentiation into adipocytes, although it does not inhibit proliferation or stimulate apoptosis. This agent also inhibits neuronal death in axons and axon regeneration in t-cell lymphomas, suggesting that this drug may be useful for treating diseases like Alzheimer's disease or stroke.Formula:C16H10ClN3O5Purity:Min. 95%Molecular weight:359.72 g/mol
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