CAS 2645-32-1: PR-619

PR-619

Applications PR 619 is a broad-range DUB inhibitor. A selective and general inhibitior of cellular DUB activity without direct impairment of proteasomal proteolysis. Used in the preparation of thiazolopyridines and bisthiazolopyridines. References Altun, M. et al.: Chem. Biol., 18, 1401 (2011); Baker, J. & Hill, S.: J. Chem. Soc., 3464 (1962)

PR-619 is a small molecule that inhibits the ubiquitin ligases Nedd4 and HECTD1, leading to the activation of autophagy. PR-619 also inhibits protease activity in cancer cells. It has been shown to specifically target microbial infections such as tuberculosis and malaria. PR-619 has shown promise for treating urothelial carcinoma, heparin-induced thrombocytopenia, mesenchymal markers, and body formation.

PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.