CAS 26478-16-0: 2,2-(Bromoethyl)-Thiophene

Oripavine is a naturally occurring alkaloid that can be synthesized from 2,2-bromoethane and potassium carbonate. It has been used for the treatment of Parkinson's disease. Oripavine is an intermediate in the synthesis of rotigotine, a dopamine agonist used to treat Parkinson's disease. The reaction mechanism involves the addition of bromine to 2,2-bromoethane followed by hydrochloric acid treatment to form oripavine. The reaction proceeds with the formation of hydrogen chloride and potassium bromide. The product can then be reacted with a Grignard reagent or allyl group to produce rotigotine.

2-(2-Bromoethyl)Thiophene

Stability Light and temperature sensitive Applications 2-(2-Thienyl)ethyl Bromide is an halogenated thiophene derivative used in the synthesis of C8813, a potent analgesic. References Liu, Z.H. et al.: Life Sci., 73, 233 (2003);