CAS 2680-81-1: Dehydrodiisoeugenol

Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.

Dehydrodiisoeugenol

Dehydrodiisoeugenol is a natural phenolic compound, which is primarily derived from the essential oil of cloves (Syzygium aromaticum). It is recognized for its antioxidative properties, which are attributed to its ability to scavenge free radicals and inhibit oxidative stress pathways in biological systems. The mode of action of dehydrodiisoeugenol involves the donation of hydrogen atoms, which enables it to neutralize reactive oxygen species, thereby protecting cells and biomolecules from oxidative damage. This mechanism is crucial in preventing the oxidative degradation of lipids, proteins, and nucleic acids. Dehydrodiisoeugenol has been studied for a range of applications, particularly in the fields of nutraceuticals and pharmaceuticals, due to its potential health benefits. It is also explored in food preservation as a natural additive to enhance shelf life by preventing oxidation. Additionally, research has investigated its antimicrobial properties and its role as a potential therapeutic agent in managing inflammation-related conditions. Researchers are continuously examining its biochemical pathways to unlock potential new uses in diverse scientific and medical fields.

Dehydrodiisoeugenol has anti-inflammatory activity, it inhibited the expression of the COX-2, proteolysis of inhibitor κB-α and transcriptional activity of NF-κB. Dehydrodiisoeugenol can cross the blood-brain barrier rapidly, it may be developed into an effective anxiogenic agent.

Oxygen-heterocyclic compound