CAS 268214-50-2: 1H-Cyclopenta[7,8]cyclopropa[4,4a]naphtho[2,3-b]furan-10b(2H)-propanoicacid,4-[(1R,4E)-1,5-dimethyl-6-oxo-4-hexen-1-yl]dodecahydro-3a,6a-dimethyl-10-methylene-9-oxo-,methyl ester, (1aS,3aR,4R,6aS,6bS,7aR,10aR,10bR)-

Coronalolide methyl ester is a naturally occurring sesquiterpene lactone ester, which is derived from Coronalolide. Its source is primarily from plants belonging to the Asteraceae family, where it is biosynthesized as part of secondary metabolism. This compound is characterized by its complex cyclic structure, which includes an esterified lactone moiety that may contribute to its biological activity. The mode of action of Coronalolide methyl ester is under investigation, but similar sesquiterpene lactones are known to interact with cellular signaling pathways, often through the modulation of enzymes or proteins involved in inflammation and cell proliferation. They may display affinity for cellular receptors, leading to perturbations in normal cellular functions, which can manifest as anti-inflammatory or antiproliferative effects. Coronalolide methyl ester holds potential for a variety of pharmacological applications, particularly in the study and treatment of inflammatory conditions and possibly in oncology, contingent upon further validation. Research efforts may focus on elucidating its biochemical interactions and therapeutic efficacy, providing valuable insights into its role as a bioactive natural product.

Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay.