CAS 26833-85-2: Harringtonine
Formula:C28H37NO9
InChI:InChI=1S/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23-,24-,27+,28-/m1/s1
InChI key:InChIKey=HAVJATCHLFRDHY-KSZYUSJVSA-N
SMILES:O(C([C@@](CCC(C)(C)O)(CC(OC)=O)O)=O)[C@H]1[C@@]2([C@@]3(N(CCC=4C2=CC5=C(C4)OCO5)CCC3)C=C1OC)[H]
Synonyms:- (4alpha)-O~3~-[(2S)-2,5-dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methylhexanoyl]cephalotaxine
- 2'R-Harringtonine
- 2′R-Harringtonine
- 4H-Cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepine, cephalotaxine deriv.
- Alkaloid C from cephalotaxus
- Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]
- Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester)
- Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester), (3(R))-
- Harringtonin
- Nsc 124147
- O~3~-[(2R)-2,5-dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methylhexanoyl]cephalotaxine
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Harringtonine
CAS:Harringtonine is a plant-derived alkaloid, which is isolated from the seeds of the Cephalotaxus species. It functions primarily by inhibiting protein synthesis within eukaryotic cells, targeting the elongation step of translation. Harringtonine binds to the ribosomal A-site cleft, halting the proper addition of amino acids to the growing polypeptide chain and thereby inducing apoptosis in rapidly dividing cells. The primary application of Harringtonine is in the field of oncology, where it is utilized for its antineoplastic properties. Research has focused on its effectiveness against various types of leukemia, where it disrupts the proliferation of cancer cells. Beyond leukemia, its potential in treating other malignancies is being explored through a variety of clinical and preclinical studies. As an area of ongoing research, the molecular mechanisms and potential for enhancing the efficacy of Harringtonine in combination therapies continue to be pivotal topics within therapeutic development.Formula:C28H37NO9Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:531.59 g/molHarringtonine
CAS:Harringtonine is a natural alkaloid that inhibitsprotein synthesis. Harringtonine has antitumor and antiviral activities. Cost-effective and quality-assured.Formula:C28H37NO9Purity:98.28% - 98.94%Color and Shape:White SolidMolecular weight:531.59Harringtonine
CAS:Formula:C28H37NO9Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:531.59Harringtonin
CAS:Controlled ProductApplications A natural product with significant antitumor activities. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Sah, N., et al.: J. Biol. Chem., 278, 20593 (2003), Lu, D., et al.: J. Int. Med. Res., 32, 488 (2004), Yunmbam, M., et al.: Oncol. Rep., 11, 833 (2004), Shao, S., et al.: Cell Biol. Int., 32, 893 (2008),Formula:C28H37NO9Color and Shape:NeatMolecular weight:531.59
