CAS 27210-57-7: Miltirone

Miltirone is a diterpenoid quinone compound, which is primarily derived from the root of Salvia miltiorrhiza, a plant traditionally used in Chinese medicine. This compound operates through multiple modes of action, including modulation of signaling pathways and induction of apoptosis in cancer cells. Miltirone's ability to interfere with these cellular processes suggests potential therapeutic applications in oncology, particularly through its interactions with cell cycle regulators and apoptosis-related proteins. Current research highlights Miltirone's promise in targeting various cancer types, owing to its capacity to impede cancer cell proliferation and survival. Moreover, its multifaceted mode of action, encompassing both caspase-dependent and independent apoptosis, positions it as a compound of interest for further investigation in chemotherapeutic strategies. Continued studies on Miltirone could elucidate its full spectrum of biological activities and potential integration into clinical cancer treatment modalities.

Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.

Miltirone

Applications An active component in Salvia miltiorrhiza that has been shown to inhibit the increase in the abundance of the mRNA for the α4 subunit of the GABAA receptor induced by ethanol withdrawal in cultured hippocampal neurons. A potential phytotherapeutic agent in the treatment of alcohol dependence. References Mostallino, M. et al.: Eur. J. Pharmacol., 494, 83 (2004); Abenavoli, L. et al.: Rec. Prog. Med. Plants, 29, 19 (2010); Colombo, G. et al.: Alcohol. Clin. Exp. Res., 30, 754 (2006);