CAS 273724-21-3: Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-,chloride, hydrate (1:1:2)

Thiamine monophosphate chloride dihydrate (Aneurine monophosphate chloride) is a compound used in the screening of ligands that promote protein stability

Applications Thiamine Monophosphate Dihydrate is a derivative compound of Thiamine Pyrophosphate Chloride (T344070). Thiamine pyrophosphate is a cofactor used to catalyze various biochemical reactions. References Andrews, F.H. et al.: Biochem., 52, 3028 (2013); Mueller, C.R., et al.: Org. Biomolec. Chem., 11, 2000 (2013); Haag, N., et al.: J. Neurosci., 32, 17842 (2012); Nemeria, N., et al.: Biochem., 51, 7940 (2012);

Thiamine monophosphate chloride (dihydrate)

Thiamine monophosphate chloride dihydrate is a form of the vitamin thiamine. It has been used in control analysis to measure the activity of enzymes that require thiamine as a cofactor, such as transketolase and pyruvate kinase. Thiamine monophosphate chloride dihydrate has also been studied in biochemical properties, where it was found that this compound can be cleaved by picolinic acid to form thiazole phosphate. The matrix effect is an important factor in polymerase chain reactions and has been shown to be dependent on the presence of dinucleotide phosphate. This compound is an essential component of energy metabolism and plays a role in protein synthesis. Thiamine monophosphate chloride dihydrate also has toxicological studies, including a model system using wild-type strains of yeast. These studies have shown that this compound leads to physiological effects such as inhibition of glycolysis and lactic acid production.