CAS 2766-74-7: 5-Chloro-2-thiophenesulfonyl chloride

5-Chlorothiophene-2-sulphonyl chloride

5-Chloro-2-thiophenesulfonyl chloride is a chemical compound that is used as an inhibitor of γ-secretase. It binds to the active conformation of the enzyme, blocking its activity and reducing the production of β-amyloid. It also inhibits the catalysis of proteolytic enzymes by azides, which may be involved in other processes such as chemokine production. 5-Chloro-2-thiophenesulfonyl chloride is a white crystalline solid that has a melting point of about 117°C and no odor at room temperature.

5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.