3,9-Dihydro-2H-purine-2-thione, with the CAS number 28128-19-0, is a heterocyclic compound that belongs to the purine family. It features a bicyclic structure composed of a fused imidazole and pyrimidine ring, with a thiol group (-SH) at the 2-position, which contributes to its reactivity and potential biological activity. This compound is characterized by its relatively low molecular weight and specific functional groups that can participate in various chemical reactions, including nucleophilic substitutions and redox reactions. It is often studied for its potential pharmacological properties, particularly in the context of its role as a purine analog, which may influence nucleic acid metabolism. The presence of the thione group can also impart unique properties, such as the ability to form coordination complexes with metal ions. Overall, 3,9-Dihydro-2H-purine-2-thione is of interest in medicinal chemistry and biochemistry for its structural features and potential applications in drug development.

3,9-Dihydro-2H-purine-2-thione

28128-19-0: 1,3-Dihydro-2H-purine-2-thione, 1H-Purine-2-thiol, 2-Mercaptopurine, 2-Thiopurine, 2H-Purine-2-thione, 1,3-dihydro-, 2H-Purine-2-thione, 1,3-dihydro- (9CI), 2H-Purine-2-thione, 3,9-dihydro-, 3,5-dihydro-2H-purine-2-thione, 3,7-dihydro-2H-purine-2-thione, 5-Mercaptopurine, Nsc 23720, Purine-2(3H)-thione, Purine-2-thiol, Purine-2-thione, 3,9-Dihydro-2H-purine-2-thione

2-Mercaptopurine (2MP) is a thiopurine drug that is used to treat bowel disease. 2MP inhibits the activity of methyltransferase, which is an enzyme that converts 6-mercaptopurine to 6-thioguanine. This process prevents the conversion of 6-thioguanine into 6-thiouric acid, which is an intermediate in the synthesis of thymine nucleotides. 2MP also inhibits the binding of atp-binding cassette transporter proteins to DNA and blocks the incorporation of purines into RNA and DNA. The drug has been shown to be effective in treating squamous cell carcinoma and other diseases with a high level of activity. 2MP has been shown to be metabolized by erythrocyte polymerase chain reaction and can be detected in biological samples.

CAS 28128-19-0: 3,9-Dihydro-2H-purine-2-thione

2-Mercaptopurine

Ref: 3D-FM02961

2-Mercaptopurine

Ref: 7W-GL6488