CAS 285983-48-4: Doramapimod
Formula:C31H37N5O3
InChI:InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
InChI key:InChIKey=MVCOAUNKQVWQHZ-UHFFFAOYSA-N
SMILES:N(C(NC=1C2=C(C(OCCN3CCOCC3)=CC1)C=CC=C2)=O)C=4N(N=C(C(C)(C)C)C4)C5=CC=C(C)C=C5
Synonyms:- 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
- 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
- 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
- 1-[5-Tert-Butyl-2-(4-Methylphenyl)Pyrazol-3-Yl]-3-[4-(2-Morpholin-4-Ylethoxy)Naphthalen-1-Yl]Urea
- Birb 796
- Birb 796Bs
- Brb 796
- N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
- Unc 10225354
- Unc10225354
- Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-
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Found 7 products.
Doramapimod
CAS:p38α MAP kinase inhibitor; JNK2α2 protein kinase inhibitorFormula:C31H37N5O3Purity:Min. 95%Color and Shape:PowderMolecular weight:527.66 g/molDoramapimod
CAS:Controlled ProductApplications Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation. References Pargellis, C. et al.: Nat. Struct. Biol., 9, 268 (2002,); Kuma, Y. et al.: J. Biol. CHem., 280, 19472 (2005); Yasui, H. et al.: Br. J. Haematol., 136, 414 (2007);Formula:C31H37N5O3Color and Shape:NeatMolecular weight:527.66Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-
CAS:Formula:C31H37N5O3Purity:99%Color and Shape:SolidMolecular weight:527.6572Doramapimod
CAS:DoramapimodFormula:C31H37N5O3Purity:99.9% (Typical Value in Batch COA)Color and Shape: off-white solidMolecular weight:527.66g/molDoramapimod
CAS:Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Formula:C31H37N5O3Purity:97.73% - 98.80%Color and Shape:SolidMolecular weight:527.66Ref: TM-T6277
1g562.00€5mg37.00€10mg55.00€25mg79.00€50mg92.00€100mg127.00€200mg225.00€500mg379.00€1mL*10mM (DMSO)44.00€Doramapimod
CAS:Formula:C31H37N5O3Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:527.67
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