2-Hydroxy-5-nitrobenzamide, with the CAS number 2912-78-9, is an organic compound characterized by the presence of both a hydroxyl group (-OH) and a nitro group (-NO2) attached to a benzamide structure. This compound typically appears as a crystalline solid and is soluble in polar solvents due to the presence of the hydroxyl group, which can engage in hydrogen bonding. The nitro group contributes to its electron-withdrawing properties, influencing its reactivity and potential applications in various chemical reactions. 2-Hydroxy-5-nitrobenzamide may exhibit biological activity, making it of interest in pharmaceutical research, particularly in the development of compounds with antimicrobial or anti-inflammatory properties. Its structural features allow for potential modifications that can enhance its efficacy or selectivity in biological systems. As with many nitro compounds, care should be taken regarding its handling and storage due to potential toxicity and environmental impact.

2-hydroxy-5-nitrobenzamide

2912-78-9: Benzamide, 2-Hydroxy-5-Nitro-, 2-HYDROXY-5-NITROBENZAMIDE

2-Hydroxy-5-nitrobenzamide (2HNB) is a nitrobenzamide derivative that has been shown to have tuberculostatic activity in vitro. This drug binds to the mycobacterial cell wall, causing the formation of intramolecular hydrogen bonds with the nitro group and oriented dipoles with the 2-hydroxy group. The 2HNB molecule is predicted to have antimycobacterial activity through intermolecular hydrogen bonding, which may be due to its ability to form hydrogen bonds with nitrous groups and oriented dipoles.

2-Hydroxy-5-nitrobenzamide

Benzamide, 2-hydroxy-5-nitro-

Applications 2-Hydroxy-5-nitrobenzamide is used in the synthesis of salicylamides and its nitro derivatives.
References Gupta, G. L.: J. Proc. Inst. Chem., 38, 165 (1966)


CAS 2912-78-9: 2-hydroxy-5-nitrobenzamide

2-Hydroxy-5-nitrobenzamide

Ref: 3D-FH116530

Benzamide, 2-hydroxy-5-nitro-

Ref: IN-DA002XE6

2-Hydroxy-5-nitrobenzamide

Ref: 10-F221770

2-Hydroxy-5-nitrobenzamide

Ref: TR-A434890