CAS: 292055-71-1

Stability Hygroscopic Applications (S,S)-Dihydro Bupropion is a metabolite of Bupropion (B689625), a selective inhibitor of dopamine uptake. References Writer, J.H., et. al.: Sci. Total Environ., 461 (2013)

(S,S)-Dihydro bupropion hydrochloride (Bupropion) is an antidepressant that is used for the treatment of major depressive disorder and seasonal affective disorder. It is a racemic mixture of the two enantiomers, (S,S) and (R,R), with the former being more active than the latter. The drug product contains a racemic mixture of (S,S) and (R,R) in a ratio of approximately 97:3. The analytical impurity in this product is N-desmethyl-bupropion. This impurity has not been found to be pharmacologically active. Bupropion may be synthesized by reacting benzaldehyde with propargyl bromide in presence of sodium hydroxide in ethanol to form a cyclic imine intermediate which is then hydrolyzed to yield bupropion

Stability Hygroscopic Applications rac-threo-Dihydro Bupropion Hydrochloride is a metabolite of Bupropion (B689625), a selective inhibitor of dopamine uptake. References Suckow, R., et al.: Drug Metab Dispos., 14, 692 (1986);