CAS 2942-07-6: 5-nitro-1,3-benzothiazole

5-Nitro-benzothiazole

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

5-Nitro-1,3-benzothiazole is a cytosolic fluorescent probe that has been shown to be activated by the presence of Ca2+. It has been used in microscopy experiments to study the uptake and distribution of 5-nitro-1,3-benzothiazole in human cervical carcinoma cells. The use of this compound as a fluorescent probe highlights the cytosolic Ca2+ concentration. 5-Nitro-1,3-benzothiazole also shows selectivity for vacuolar versus cytoplasmic Ca2+, with it being more distributed in the latter. This compound is synthesized from nitric acid and benzene through two steps: nitration followed by hydrolysis. The first step produces nitronitrosobenzene, which reacts with hydrogen peroxide to form an intermediate called aestivum. Aestivum then reacts with ammonia to form 5-nitrobenzoic acid which

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