P-tolyl trifluoromethanesulfonate, also known as p-tolyl triflate, is an organic compound characterized by the presence of a p-tolyl group (a para-substituted toluene) attached to a trifluoromethanesulfonate moiety. This compound is typically a colorless to pale yellow liquid and is known for its high reactivity, particularly as an electrophilic reagent in organic synthesis. The triflate group is a potent leaving group, making p-tolyl trifluoromethanesulfonate valuable in various nucleophilic substitution reactions. It is often used in the formation of carbon-carbon and carbon-heteroatom bonds, facilitating the synthesis of complex organic molecules. Additionally, the presence of trifluoromethyl groups enhances the compound's stability and solubility in polar solvents. Safety precautions should be observed when handling this compound, as it can be harmful if inhaled or absorbed through the skin. Overall, p-tolyl trifluoromethanesulfonate is a versatile reagent in synthetic organic chemistry, contributing to the development of pharmaceuticals and other fine chemicals.

P-tolyl trifluoromethanesulfonate

29540-83-8: 4-Methylphenyl Trifluoromethanesulfonate

4-Methylphenyl trifluoromethanesulphonate

The reaction of 4-methylphenyl trifluoromethanesulfonate with aryl Grignard reagents provides an efficient route to the synthesis of chiral organic compounds. The reaction proceeds in high yield and with excellent stereoselectivity. The mechanism involves Pd-catalyzed coupling of the electrophilic methyl group on the sulfonate with a nucleophilic carbon atom on the Grignard reagent. This process is thought to proceed through a sequence of steps including hydroxy group activation, acyl transfer, and elimination.

CAS 29540-83-8: P-tolyl trifluoromethanesulfonate

4-Methylphenyl trifluoromethanesulphonate

Ref: 54-PC500030

4-Methylphenyl Trifluoromethanesulfonate

Ref: 3D-FM85482

P-Tolyl trifluoromethanesulfonate

Ref: 10-F062634

p-Tolyl Trifluoromethanesulfonate

Ref: 3B-T2606

Methanesulfonic acid, 1,1,1-trifluoro-, 4-methylphenyl ester

Ref: IN-DA002YP5