CAS 29545-48-0: 5-Doxylstearic acid

Applications 5-DOXYL-stearic Acid, Free Radical is a spin label that is used for investigating structural changes in lipids. 5-DOXYL-stearic Acid, Free Radical can also be used in biological study of C-edge loops of arrestin function as membrane anchor. References Lally, C. C. M., et al.: Nat Commun, 8, 14258 (2017)

5-Doxyl stearic acid chloride is a chemical that has been shown to be a potent inhibitor of the metabolic activity of human HL-60 cells. This agent is stable and soluble in organic solvents, making it suitable for use in biological systems. 5-Doxyl stearic acid chloride has been used as a model system to study membrane permeability and energy metabolism, as well as the physiological effects of cyclic peptides. 5-Doxyl stearic acid chloride can also be used as an antimicrobial agent by binding to bacterial membranes and preventing the synthesis of DNA. It is also able to inhibit the growth of bacteria by binding to cell wall receptors. 5-Doxyl stearic acid chloride may have applications in weight loss therapy due to its ability to reduce body mass index (BMI) levels in animals.

5-Doxyl stearic acid is an agonist of the G protein coupled receptor. It has been shown to activate energy metabolism in human neutrophils and HL-60 cells, as well as guanine nucleotide binding and transmembrane transport. 5-Doxyl stearic acid was found to have no significant effect on the regulation of cellular membrane fluidity or on the permeability of biological membranes. It also has no significant effects on human erythrocytes, human serum, or human plasma. This compound is a cyclic peptide with a magnesium salt that can be used for fluorescent probe studies and has been used to develop a model system for studying G protein coupled receptors.