CAS 29606-06-2: 5-Pyrimidinemethanol,2,4-diamino-a-(3,4,5-trimethoxyphenyl)-

Applications α-Hydroxy Trimethoprim is an impurity of Trimethoprim (T795615), an antibacterial agent that is commonly prescribed in conjunction with Sulfametoxazole (S699086) to treat patients afflicted with urinary tract infections. References Dauber-Osguthorpe, P., et al.: Proteins, 4, 31, (1988); Darrell, J., et al.: J. Clin. Pathol., 21, 202 (1968); Zhanel, G., et al.: Antimicrob. Agents Ch., 44, 1089 (2000)

Applications α-Hydroxy Trimethoprim-D3 is a labelled analogue of α-Hydroxy Trimethoprim (H971985).

Ro 20-0657/000 is a metabolite of Trimethoprim, a dihydrofolate reductase inhibitor used as an antibacterial in medicine.

α-Hydroxy trimethoprim (impurity) is a nonsteroidal anti-inflammatory drug that has been used for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is metabolized in the liver to produce a carboxylic acid metabolite with anti-inflammatory properties. The hydroxyl group on α-hydroxy trimethoprim can be converted to an amide, which can be transformed into enalaprilat. This impurity also inhibits the production of glucose by cells in the pancreas and helps to control blood sugar levels in patients with diabetes mellitus type 2. The structure of α-hydroxy trimethoprim may also have reactivity with glutathione or cytochrome P450 enzymes.