CAS 308103-40-4: 2-Acetylphenylboronic acid

2-Acetylphenylboronic acid is a covalent boronate ester that is stable in aqueous solutions. It has been shown to be effective for the diagnosis of bacterial strains and can be used for the treatment of cancer. This compound has also been studied for its use as an antimicrobial agent against methicillin-resistant Staphylococcus aureus (MRSA), which may lead to new treatments for MRSA infections. The reaction mechanism of 2-acetylphenylboronic acid involves neutral ph, aristolactam, and diazaborine intermediates. 2-Acetylphenylboronic acid is also a reversible covalent with kinetic properties that can be used in chemical biology experiments.

2-Acetylbenzeneboronic acid

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications 2-Acetylphenylboronic Acid is a reactant used in the synthesis of potent, selective phenylimidazole-based tissue factor/factor VIIa (FVIIa) inhibitors. References Glunz, P.W., et. al.: Bioorg. Med. Chem. Lett., 25, 21699 (2015)

2-Acetylphenylboronic acid is a reactant used for a variety of coupling reactions, as well as synthesis and hydroxy masking, Suzuki-Miyaura cross-coupling reactions, rhodium-catalyzed annulation of ynamides, transient masking of hydroxy groups, cationic palladium complex-catalyzed diastereoselective tandem annulation, hydrogen peroxide mediated formation of heteroaryl ethers and copper-catalyzed transmetalation and homocoupling. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.