CAS: 313263-08-0

Geranylgeranyl pyrophosphate triammonium salt (GGPP) is a natural compound found in the essential oil of plants such as pine trees. GGPP has been shown to inhibit cancer cell growth and induce apoptotic cell death. GGPP binds to the ATP-binding cassette transporter and inhibits the expression of receptor α, which is an important regulator of cancer cell growth. GGPP also inhibits the production of growth factor, which promotes cancer cell proliferation. GGPP has also been shown to be effective against some cancers that are resistant to statins, such as breast cancer cells. In addition, GGPP induces autophagy and inhibits the activity of aromatic hydrocarbon-induced activated protein kinase C (aPKC), which is involved in regulating cellular proliferation.

Geranylgeranyl Pyrophosphate triammonium (GGPP triammonium) regulates endothelial cell proliferation and apoptosis during mouse embryo vasculogenesis.