CAS 313545-41-4: 4-Chloro-2-(trifluoromethyl)benzeneboronic acid

4-Chloro-2-(trifluoromethyl)benzeneboronic acid

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

4-Chloro-2-(trifluoromethyl)phenylboronic acid (4CFPBA) is a fluorescent derivative of the boronic acid that functions as a ligand and can be used to detect tumor cells. 4CFPBA binds to placental alkaline phosphatase, an antigen found on tumor cells, and has been shown to redirect these cells to be more susceptible to antibody-mediated cell killing. This compound also has a high affinity for its ligand, which makes it useful as a bispecific reagent. 4CFPBA is activated by light with a wavelength of 365 nm and emits fluorescence at 635 nm. It is not only detectable but also shows excellent stability in the presence of serum proteins.