CAS 313967-18-9: FLI-06

Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate is a hormone analog that has been shown to have potent thyroxine releasing activity. It is also a methyltransferase inhibitor that blocks the synthesis of thyroxine by inhibiting the enzyme responsible for this process. This drug can be used to treat hypothyroidism in adults and children. Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline 3 carboxylic acid has been shown to induce pluripotent stem cells from mouse embryonic fibroblasts. These cells are then differentiated into different cell types such as neurons and pancreatic islet cells

FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).

Applications FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway. References Kraemer, A., et al.: Nat. Chem. Biol., 9, 731 (2013)

FLI-06