Procathepsin B (26-50) is a peptide derived from the proenzyme form of cathepsin B, a cysteine protease predominantly found in lysosomes. This specific fragment corresponds to amino acids 26 to 50 of the procathepsin B sequence, which plays a crucial role in the activation and regulation of cathepsin B activity. The CAS number 317331-27-4 identifies this particular peptide, which is often used in research related to protein processing, cellular signaling, and the study of various diseases, including cancer and neurodegenerative disorders. Procathepsin B is characterized by its involvement in the degradation of extracellular matrix components and its potential role in tumor progression. Its structure typically includes a sequence of amino acids that contribute to its stability and function, and it may exhibit specific binding properties or interactions with other biomolecules. As a research tool, it can be utilized in assays to investigate proteolytic activity and the physiological roles of cathepsin B in various biological contexts.

Procathepsin B (26-50) (rat)

317331-27-4: H-Ala-Gly-Arg-Asn-Phe-Tyr-Asn-Val-Asp-Ile-Ser-Tyr-Leu-Lys-Lys-Leu-Cys-Gly-Thr-Val-Leu-Gly-Gly-Pro-Lys-NH2, L-Lysinamide, L-alanylglycyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-tyrosyl-L-asparaginyl-L-valyl-L-a-aspartyl-L-isoleucyl-L-seryl-L-tyrosyl-L-leucyl-L-lysyl-L-lysyl-L-leucyl-L-cysteinylglycyl-L-threonyl-L-valyl-L-leucylglycylglycyl-L-prolyl-

This 25 residue peptide was completely resistant to proteolysis by cathepsin B even after incubation overnight. It inhibited human cathepsin B with Ki = 2.8 µM and rat cathepsin B with Ki = 2 µM.

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CAS 317331-27-4: Procathepsin B (26-50) (rat)

Procathepsin B (26-50) (rat)

Ref: 01-4028254

Procathepsin B (26-50) (rat)

Ref: 3D-FP109126