CAS 32113-41-0: (4-acetamidophenoxy)sulfonyloxypotassium

Acetaminophen-induced hepatotoxicity is a serious adverse effect that can occur with the use of acetaminophen. This drug is metabolized by the liver and excreted in urine as conjugates with glucuronic acid, sulfate, and glutathione. Acetaminophen-induced hepatotoxicity is a major concern for wastewater treatment plants. The potential harm to humans is determined by the plasma concentration of acetaminophen. A pharmacokinetic study was performed on human volunteers to determine the pharmacokinetics of 4-acetaminophen sulfate potassium salt following oral administration. The study found that 4-acetaminophen sulfate potassium salt has linear pharmacokinetics and an activated half-life of 6 hours. This means that it would take 6 hours for 50% of the drug to be eliminated from the body after ingestion. In addition, electrochemical impedance spectroscopy has been used to measure plasma concentrations in humans following oral administration of 4-acetaminohen