![2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fcas-image%2Fthumb-webp%2F107513-2-3-13-dioxo-1h-benz-de-isoquinolin-2-3h-yl-propyl-thio-benzoic-acid.webp&w=3840&q=75)
CAS 325850-81-5: 2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
Formula:C22H17NO4S
InChI:InChI=1S/C22H17NO4S/c24-20-16-9-3-6-14-7-4-10-17(19(14)16)21(25)23(20)12-5-13-28-18-11-2-1-8-15(18)22(26)27/h1-4,6-11H,5,12-13H2,(H,26,27)
InChI key:InChIKey=GMVZUCHUOYUMLL-UHFFFAOYSA-N
SMILES:O=C1C=2C=3C(C(=O)N1CCCSC4=C(C(O)=O)C=CC=C4)=CC=CC3C=CC2
Synonyms:- GRI 977143
- 2-[3-(1,3-Dioxobenzo[de]isoquinolin-2-yl)propylsulfanyl]benzoic acid
- 2-[[3-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
- 2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
- Benzoic acid, 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-
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GRI977143
CAS:GRI977143 is a specific agonist of the growth factor G-protein coupled receptor 9 (GPR9). It inhibits chemoresistance, which is a resistance to chemotherapy caused by cancer cells. GRI977143 has been shown to be effective against prostate cancer cells in vitro and in vivo. GRI977143 also exhibits apoptotic effects on these cells, which may be mediated by cyclase inhibition. Additionally, GRI977143 has been shown to inhibit fibroblast proliferation and cellular function in rats with inflammatory diseases. This drug also induces apoptosis pathway in cancer cells and can induce apoptosis in these cells as well as blocking cell proliferation.Formula:C22H17NO4SPurity:Min. 95%Molecular weight:391.44 g/mol2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid
CAS:Formula:C22H17NO4SPurity:95%Color and Shape:SolidMolecular weight:391.43967999999995GRI977143
CAS:GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.Formula:C22H17NO4SPurity:98.07%Color and Shape:SolidMolecular weight:391.44
![2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00C9GE.jpg&w=3840&q=75)
