CAS 325855-74-1: 2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, 1'-oxide

Applications Etoricoxib N1’-Oxide is an impurity of Etoricoxib (E934100). References Friesen, R., et al.: Bioorg. Med. Lett., 8, 2777 (1998), Botting, J., et al.: Drugs of Today, 35, 225 (19990, Talley, J., et al.: J. Med. Chem., 43, 775 (2000),

Etoricoxib N-Oxide is a non-steroidal anti-inflammatory drug (NSAID) that is used to treat inflammation and pain. Etoricoxib N-Oxide has a short half-life, which is due to its rapid metabolism by CYP2C9 and CYP3A4. This drug has been shown to be effective in reducing the incidence of ulcers in horses treated with it orally for 3 months. Etoricoxib N-Oxide also inhibits the production of prostaglandins, which are substances that cause pain and inflammation. NSAIDs like etoricoxib N-Oxide inhibit the activity of cyclooxygenase (COX), an enzyme that converts arachidonic acid into prostaglandins. The inhibition of COX prevents the formation of prostaglandin H2 from arachidonic acid, which is a precursor to other prostaglandins such as PGE2 and PGD2. Et