CAS: 328543-09-5

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AG 14361 is a potent inhibitor designed to target the interaction between the tumor suppressor protein p53 and the murine double minute 2 (MDM2) oncoprotein. It is synthetically derived, offering researchers a tool to perturb a critical protein-protein interaction involved in the regulation of the cell cycle and apoptosis. The mode of action involves the disruption of the p53-MDM2 interaction, leading to the stabilization and activation of p53. This results in the induction of p53-dependent transcriptional activity, facilitating cell cycle arrest and apoptosis in cancerous cells. AG 14361 is primarily used in the context of cancer research, particularly in studies aiming to understand the mechanisms underlying tumor suppression. By inhibiting the interaction between p53 and MDM2, AG 14361 provides insights into the reactivation of p53 pathways in cancers where this pathway is otherwise compromised. It serves as a crucial research tool for exploring therapeutic strategies that could potentially mimic this effect in oncological settings.

AG14361

AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).