CAS 331943-04-5: Benzenesulfonamide,4-[3-(4-methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]-

Sulfonamides, nesoi

N-De(4-sulfonamidophenyl)-N'-(4-sulfonamidophenyl) celecoxib is an impurity of the drug celecoxib. It is a synthetic chemical compound that has been used in the synthesis of the drug celecoxib. N-De(4-sulfonamidophenyl)-N'-(4-sulfonamidophenyl) celecoxib is a crystalline solid with melting point at 136º C. It is soluble in chloroform, ethanol and acetone and insoluble in water. The chemical compound has been isolated by using a supercritical fluid chromatography technique and characterized by means of various analytical techniques such as fluid chromatography, crystallization, product yield, bulk drug, supercritical fluid chromatography, and chromatographic methods. This chemical compound has been found to contain contaminants such as metal ions (Zn2+, Ca2+, Mg2+) which can be

Impurity Celecoxib EP Impurity B Applications N-De(4-sulfonamidophenyl)-N’-(4-sulfonamidophenyl) Celecoxib (Celecoxib EP Impurity B) is an isomeric impurity of Celecoxib (C251000) with selective inhibitory activity against human cyclooxygenase-2. USP Celecoxib Related Compound B References Talley, J.J. et al.: Actual. Chim. Therap., 25, 123 (1999); Rao, R. et al.: Anal. Sci., 22, 1257 (2006);