CAS 33213-65-9: β-Endosulfan

Endosulfan II, an organochlorine insecticide and a stereoisomer of Endosulfan I, effectively targets various insects such as bollworms and tobacco budworms, with lethal doses (LD50s) of 4.14 and 4.95 mg/g, respectively. It interacts with GABA receptors in rat brain membranes, demonstrating an inhibition concentration (IC50) of 60 nM. Notably, Endosulfan II exhibits lower toxicity in rats compared to Endosulfan I, with LD50 values of 240 and 18 mg/kg, respectively.

Endosulfan is a pesticide that belongs to the class of organochlorine compounds. It has been used extensively in agriculture, forestry, and public health programs for mosquito control. Endosulfan can cause chronic exposure in humans and animals at levels above its threshold limit value (TLV). The compound is lipophilic and readily penetrates human skin. It also accumulates in adipose tissue, which leads to long-term exposure. Endosulfan is metabolized by gamma-aminobutyric acid (GABA) into endosulfan sulfate, which is excreted in the urine. Endosulfan has been shown to have growth-inhibiting effects on animal cells and can affect the GABA receptors of mammalian brain cells. Linear regression analysis has shown a correlation between endosulfan levels in maternal serum and weight in children born to women with high exposure to endosulfan during pregnancy.

Applications β-Endosulfan is the beta isomer of Endosulfan (E555505), an insecticide that poses health risks to humans and animals that acquire it through ingension, inhalation, and percutaneous contact. One of the new POPs under the Stockholm Convention. Useful in cannabis testing kits as a component of pesticide mixes (P698230). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bhalerao, T. & Puranik, P.: Int. Biodeter. Biodegr., 59, 315 (2007); Kalender, S., et al.: Toxicology, 202, 227 (2004); Naqvi, S. & Vaishnavi, C.: Comp. Biochem. Phys. C, 105, 347 (1993)