Mdivi-1, or 1-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl) urea, is a small molecule known for its role as a selective inhibitor of mitochondrial division. It primarily targets the dynamin-related protein 1 (Drp1), which is crucial for mitochondrial fission. By inhibiting Drp1, Mdivi-1 can influence mitochondrial morphology and function, making it a valuable tool in research related to mitochondrial dynamics and associated diseases. The compound has been studied for its potential neuroprotective effects, particularly in models of neurodegeneration, as well as its implications in cancer biology, where altered mitochondrial dynamics can contribute to tumor progression. Mdivi-1 is typically characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can affect its bioavailability in biological systems. As with many small molecules, its pharmacokinetics and toxicity profiles are important considerations for its application in experimental settings. Overall, Mdivi-1 serves as a significant compound in the study of mitochondrial biology and therapeutic interventions.

Mdivi-1

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Applications Mdivi-1 is an inhibitor of mitochondrial division DRP1 and Dynamin I.


Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM).

Mitochondrial division inhibitor (mdivi-1) inhibits dynamin related protein-1 (drp1)-dependent mitochondrial fission. It is a therapeutic candidate for the treatment of stroke, myocardial infarction and neurodegenerative disease. The neuroprotective effects of mdivi-1 has been demonstrated in various models of brain ischemia and neurodegeneration.

CAS 338967-87-6: Mdivi-1

Mdivi-1

Ref: TR-M199505

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Ref: 3B-M3108

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Ref: 3D-FD65075