CAS 33948-22-0: 5H-Dibenz[b,f]azepine-5-carbonyl chloride

5H-Dibenzo[b,f]Azepine-5-Carbonyl Chloride

Iminostilbene N-carbonyl chloride is an antimicrobial agent that inhibits the activity of cation channels in bacterial cells. It has been shown to be effective against P. aeruginosa and other bacteria, including Mycobacterium tuberculosis, with a minimal toxicity profile. The mechanism of action is not yet fully understood, but it may involve inhibition of the ion channel or direct interaction with the cell membrane. Iminostilbene N-carbonyl chloride was used to produce monoclonal antibodies against human inflammatory disease targets. These antibodies were produced by immunizing mice with imeostilbene N-carbonyl chloride and then extracting mouse spleen cells to produce hybridomas. One study showed that imeostilbene N-carbonyl chloride inhibited fatty acid synthesis in a model system of rat liver cells.

Applications Desamino Chloro Carbamazepine-d2 is an intermediate in the synthesis of Carbamazepine-d2,15N (C175841), the labeled analogue of Carbamazepine (C175840), used in treatment of pain associated with trigeminal neuralgia. Anticonvulsant. References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)

Impurity Carbamazepine EP Impurity F Stability Hygroscopic, Moisture Sensitive Applications Iminostilbene N-Carbonyl Chloride is an intermediate in the preparation of Carbamazepine (C175840). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bellucci, G., et al.: J. Med. Chem., 30, 768 (1987), Takayama, H., et al.: Bioorg. Med. Chem. Lett., 17, 4729 (2007),