Methyl pyrimidine-5-carboxylate, with the CAS number 34253-01-5, is an organic compound characterized by its pyrimidine ring structure, which is a six-membered aromatic heterocycle containing two nitrogen atoms at positions 1 and 3. This compound features a carboxylate functional group (-COO-) attached to the fifth position of the pyrimidine ring, along with a methyl group (-CH3) esterified to the carboxylic acid. Methyl pyrimidine-5-carboxylate is typically a colorless to pale yellow liquid or solid, depending on its purity and form. It is soluble in polar organic solvents, making it useful in various chemical reactions and syntheses. The compound is of interest in medicinal chemistry and agricultural applications, often serving as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its reactivity is influenced by the electron-withdrawing nature of the carboxylate group, which can participate in nucleophilic substitution and other organic transformations. Safety data should be consulted for handling and storage, as with all chemical substances.

Methyl pyrimidine-5-carboxylate

34253-01-5: 5-Pyrimidinecarboxylic acid, methylester, 5-Pyrimidinecarboxylic acid, methyl ester

Methylpyrimidine-5-carboxylate is a tyrosine kinase inhibitor that binds to the nitrogen atoms of the active site. It selectively inhibits the activity of protein kinases, including tyrosine kinase. Methylpyrimidine-5-carboxylate has been shown to have high inhibitory activity against tyrosine kinases, and it exhibits potent inhibition against a number of tumor cell lines in vitro. Methylpyrimidine-5-carboxylate inhibits enzymatic activity by alkylating the hydroxyl group on the active site as well as binding to the chloride ion. This drug has shown no signs of toxicity in animals and is currently being studied for its use as an anticancer drug.

CAS 34253-01-5: Methyl pyrimidine-5-carboxylate

Methyl pyrimidine-5-carboxylate

Ref: IN-DA00362Z

Methyl pyrimidine-5-carboxylate

Ref: 10-F225096

Methyl pyrimidine-5-carboxylate

Ref: 54-OR305379

Methylpyrimidine-5-carboxylate

Ref: 3D-FM153049