CAS 34298-86-7: Rhein 8-O-β-D-glucopyranoside

Natural glycoside

Applications Rhein 8-Glucoside has been seen to exhibit cytotoxic and DNA-damaging properties towards tumor and normal human cells. In addition it has been shown to be an inhibitor of PTP1B (Human Protein Tyrosine Kinase 1B) in vitro. It is an analog of Rhein (R318500) which is found in the free state and as glucoside in Rheum spp, Polygonaceae (rhubarb) and in Senna leaves. It is a potential antioxidant resource: endophytic fungi from medicinal plants. References Wanitschke, Pharmacology, 20, Suppl. 1, 21 (1980); Raimondi, L., et al.: Pharmacol. Res. Commun., 14, 103 (1982); Franchi-Micheli, S., et al.: J. Pharm. Pharmacol., 35, 262 (1983); Li, S. et al.: J. Asian Nat. Prod. Res., 8, 281 (2006); Shi, Y.Q. et al.: Anticancer. Res., 21, 2847 (2001);

Rhein 8-Glucoside (Rhein-8-glucoside) has low laxative activity.

Rhein 8-Glucoside

Rhein-8-glucoside is a naturally occurring anthraquinone glycoside, which is derived primarily from the roots of plants such as Rheum species. These plants have been traditionally used in herbal medicine, and the glycoside form of Rhein enhances its solubility and bioavailability. The mode of action of Rhein-8-glucoside involves the modulation of various cellular pathways, including the inhibition of specific enzymes and the interaction with cellular receptors, potentially leading to anti-inflammatory, antioxidant, and antimicrobial effects. The uses and applications of Rhein-8-glucoside are predominantly in scientific research, where it is utilized to explore its pharmacological potential and understand its role in various biological processes. Researchers investigate its efficacy and mechanisms in the context of disease models, aiming to discover new therapeutic insights or adjunctive treatment strategies. Its study is particularly relevant in the fields of pharmacology and medicinal chemistry, where scientists are interested in its molecular interactions and potential health benefits. As research progresses, Rhein-8-glucoside continues to be an intriguing compound for ongoing investigation in natural product chemistry and drug discovery.