2'-Deoxy-5-(trifluoromethyl)uridine 5'-(dihydrogen phosphate) is a nucleoside analog characterized by the presence of a trifluoromethyl group at the 5-position of the uridine base. This modification can influence the compound's biological activity and stability. The molecule features a deoxyribose sugar, which lacks an oxygen atom at the 2' position, distinguishing it from ribonucleosides. The 5' phosphate group, existing as a dihydrogen phosphate, contributes to the compound's solubility and reactivity, making it relevant in biochemical applications, particularly in nucleic acid research and drug development. The trifluoromethyl group enhances lipophilicity and can affect the compound's interaction with enzymes and nucleic acids. Overall, this substance is of interest in medicinal chemistry and molecular biology due to its potential as an antiviral or anticancer agent, as well as its utility in studying nucleic acid metabolism and function.

2'-deoxy-5-(trifluoromethyl)uridine 5'-(dihydrogen phosphate)

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2'-Deoxy-5-trifluoromethyluridine-5'-monophosphate is a prodrug that has been shown to inhibit the growth of endothelial cells. It has also been shown to be effective against cancer cells, specifically those that are resistant to other chemotherapeutic agents. The mechanism of action is not yet known, but it may be due to inhibition of thymidylate synthase and DNA synthesis. 2'-Deoxy-5-trifluoromethyluridine-5'-monophosphate is a potential drug for use in the treatment of cancer. Clinical trials have shown that it can promote tumor regression in patients with advanced solid tumors.

CAS 345-02-8: 2'-deoxy-5-(trifluoromethyl)uridine 5'-(dihydrogen phosphate)

2'-Deoxy-5-trifluoromethyluridine-5'-monophosphate

Ref: 3D-ND102878