2'-Deoxy-5-(trifluoromethyl)uridine 5'-(tetrahydrogen triphosphate), commonly referred to as a modified nucleotide, exhibits several notable characteristics. This compound is a derivative of uridine, where the 5-position of the uracil base is substituted with a trifluoromethyl group, enhancing its lipophilicity and potentially influencing its biological activity. The presence of the triphosphate moiety is crucial for its role in biochemical processes, particularly in nucleic acid synthesis and energy transfer. The trifluoromethyl group can also impart unique properties, such as increased stability against enzymatic degradation and altered binding affinities to nucleic acid targets. This compound is often utilized in research and therapeutic applications, particularly in the development of antiviral agents or as a tool in molecular biology for studying nucleic acid interactions. Its CAS number, 345-03-9, allows for easy identification and reference in chemical databases. Overall, the structural modifications of this nucleotide contribute to its distinctive chemical behavior and potential utility in various scientific fields.

2'-deoxy-5-(trifluoromethyl)uridine 5'-(tetrahydrogen triphosphate)

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The compound [(2R,3S,5R)-5-[2,4-Dioxo-5-(Trifluoromethyl)Pyrimidin-1-Yl]-2,3,6,7-Tetrahydro-4H-pyrrolo[1,2-C]Pyrazol[4,3-C]Quinoline (TPQ) is a DNA polymerase inhibitor that inhibits the synthesis of viral DNA. TPQ is a competitive inhibitor with respect to natural nucleoside triphosphates and interacts with the enzyme's active site. TPQ has been shown to inhibit the synthesis of deoxyadenosine triphosphate in uninfected cells and in cells infected with HIV. The compound TPQ has also been shown to be an effective inhibitor of human DNA polymerases alpha and beta.

CAS 345-03-9: 2'-deoxy-5-(trifluoromethyl)uridine 5'-(tetrahydrogen triphosphate)

[(2R,3S,5R)-5-[2,4-Dioxo-5-(Trifluoromethyl)Pyrimidin-1-Yl]-

Ref: 3D-FD103845