β,γ-Methylene ATP is a synthetic analog of adenosine triphosphate (ATP) that is characterized by the presence of a methylene group in place of the γ-phosphate group. This modification imparts unique biochemical properties to the molecule, making it a potent and selective agonist for purinergic receptors, particularly P2X and P2Y receptor subtypes. The compound is known for its ability to mimic ATP's action in cellular signaling pathways while being resistant to hydrolysis by ATPases, which enhances its stability in biological systems. β,γ-Methylene ATP is often used in research to study purinergic signaling, muscle contraction, and neurotransmission. Its structural modifications allow it to interact with various enzymes and receptors, providing insights into ATP's role in physiological and pathological processes. Additionally, due to its specificity, it serves as a valuable tool in pharmacological studies aimed at understanding the mechanisms of action of purinergic compounds.

β,γ-Methylene ATP

3469-78-1: 5'-Adenylic acid, monohydride with methylenebis(phosphonic acid), 5'-Adenylyl (beta,gamma-methylene)diphosphonate, 5'-O-(hydroxy{[hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl)adenosine, 5′-Adenylic acid, 5′-anhydride with P,P′-methylenediphosphonic acid, 5′-Adenylic acid, anhydride with methylenediphosphonic acid, 5′-Adenylic acid, monoanhydride with methylenebis[phosphonic acid], 5′-Adenylic acid, monoanhydride with methylenediphosphonic acid, 5′-Adenylyl methylenediphosphonate, 5′-Adenylyl methylenediphosphonic acid, ATP, β,γ-methylene-, Adenosine 5′-(β,γ-methylene)triphosphate, Adenylyl (β,γ-methylene)diphosphonate, Adenylyl methylenediphosphonate, Phosphonic acid, methylenedi-, monoanhydride with 5′-adenylic acid, β,γ-Methylene 5′-ATP, β,γ-Methylene ATP, β,γ-Methylene adenosine 5′-triphosphate, β,γ-Methylene adenosine triphosphate

AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.

CAS 3469-78-1: β,γ-Methylene ATP

AMP-PCP

Ref: TM-T13547