CAS: 349554-02-5

(S,S,S)-Enalapril-d5 maleate is a deuterated analogue of enalapril maleate, a pharmaceutical compound used as an angiotensin-converting enzyme (ACE) inhibitor. This isotopically labeled form is synthetically derived to incorporate five deuterium atoms, serving as a critical tool in mass spectrometry studies. By replacing hydrogen atoms with deuterium, this compound enables precise measurements in pharmacokinetic and metabolic research. The mode of action for (S,S,S)-Enalapril-d5 maleate involves inhibiting ACE, thereby reducing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action results in vasodilation, decreased blood pressure, and reduced strain on the cardiovascular system. Uses and applications of (S,S,S)-Enalapril-d5 maleate predominantly focus on its role in research settings. It is employed in the quantification of enalapril in complex biological matrices. Additionally, its use in studies of drug metabolism and interactions involves examining the deuterium kinetic isotope effect, providing insights into biochemical pathways. This compound is central to developing more accurate dosing regimens and therapeutic strategies for hypertension and related cardiovascular conditions.

Enalapril D5 maleate is deuterium labeled Enalapril, which is an angiotensin converting enzyme (ACE) inhibitor.